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Outer membrane vesicles transmit blaNDM-5 and package metallo-β-lactamases to promote antibiotic resistance in Escherichia coli - PubMed

4 hours ago
  • #Carbapenemase
  • #Antibiotic Resistance
  • #Outer Membrane Vesicles
  • OMVs from E. coli with blaNDM-5 transfer plasmids and active carbapenemase, boosting antibiotic resistance.
  • These vesicles raise meropenem MICs >500-fold in recipients and degrade antibiotics extracellularly.
  • Proteomic changes in OMVs reflect bacterial adaptations to carbapenem exposure.