Ferroptosis in cardiovascular diseases: molecular mechanisms and a novel therapeutic target - PubMed
5 days ago
- #Cardiovascular Diseases
- #Therapeutic Targets
- #Ferroptosis
- Ferroptosis is a regulated cell death mechanism driven by iron accumulation and lipid peroxidation, playing a key role in cardiovascular diseases (CVDs).
- Preclinical studies show that modulating ferroptosis can reduce myocardial and vascular injury, but clinical application is limited by a lack of understanding, biomarkers, and safe therapeutics.
- The molecular mechanisms of ferroptosis involve iron homeostasis, lipid peroxidation, and antioxidant defense systems.
- Ferroptosis contributes to various CVDs, including atherosclerotic plaque instability, myocardial ischemia-reperfusion injury, heart failure, cardiomyopathies, and hypertensive cardiac remodeling.
- Emerging therapeutic strategies include iron chelation, radical-trapping antioxidants, GPX4-modulating agents, and nanomedicine-based delivery platforms.
- Potential biomarkers for clinical translation include lipid peroxidation products, iron metabolism indices, regulatory non-coding RNAs, and imaging surrogates.
- Ferroptosis represents a promising target for precision diagnostics and therapies to reduce the global burden of CVDs.