Clinical Impact of Postrecanalization Hemorrhagic Transformation and Its Prediction Using Baseline Noncontrast CT - PubMed
3 days ago
- #hemorrhagic transformation
- #ischemic stroke
- #recanalization therapy
- Hemorrhagic transformation (HT) after recanalization therapy is a critical concern in acute ischemic stroke management.
- The study analyzed 2211 patients receiving intravenous thrombolysis and endovascular thrombectomy from the multicenter Clinical Research Collaboration for Stroke in Korea Imaging repository (2022-2024).
- HT was classified into subtypes: hemorrhagic infarction (HI) 1, HI2, parenchymal hematoma (PH) 1, and PH2, with varying prevalence.
- All HT subtypes independently predicted worse functional recoveries, with increasing odds ratios from HI1 to PH2.
- The automated imaging model for PH prediction achieved superior performance (AUC 0.77) compared to conventional scores like hemorrhage after thrombolysis score (AUC 0.71) and SEDAN (AUC 0.72).
- Even mild HI was associated with poor functional outcomes after reperfusion therapy.
- Automated noncontrast CT-derived biomarkers provide superior HT risk prediction compared to conventional scores, aiding individualized stroke management.