Metabolic networks in the tumor microenvironment: roles of amino acid and lipid metabolism pathways in cancer progression and therapy - PubMed
3 hours ago
- #cancer metabolism
- #tumor microenvironment
- #metabolic therapy
- Metabolic rewiring is a hallmark of cancer, supporting cell proliferation and biosynthesis.
- The tumor microenvironment (TME) includes stromal, immune, and endothelial cells forming a complex metabolic network.
- Nutrient fluxes in the TME influence immune evasion, therapeutic resistance, and metabolic symbiosis.
- Key metabolites like glutamine, arginine, tryptophan, branched-chain amino acids, and lipids play dual roles in immune regulation and tumor growth.
- Traditional single-pathway targeting is limited; a network-centric therapeutic approach is advocated.
- Metabolite-derived signaling and epigenetic regulation reinforce immune suppression and cell state transitions.
- Emerging therapeutic strategies include multitarget combinations and immune-metabolic synergies.
- Spatial metabolomics, liquid biopsy platforms, and AI-driven modeling are needed for precision metabolic interventions.