Diagnostic Performance of New Commercial IGRAs for Mycobacterium tuberculosis Infection: An updated Systematic Review and Meta-analysis - PubMed
4 hours ago
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- #IGRAs
- #diagnostic tests
- WHO endorses several commercial Interferon Gamma Release Assays (IGRAs) for Mycobacterium tuberculosis infection.
- A systematic review and meta-analysis compared the performance of new IGRAs with WHO-endorsed ones.
- Eight new IGRAs were evaluated, including STANDARD E TB-Feron and LIAISON XL Analyzer (CLIA).
- STANDARD E TB-Feron showed non-significantly lower sensitivity and specificity compared to QFT-plus.
- LIAISON XL Analyzer had comparable specificity and high agreement with QFT-Plus/GIT.
- Overall certainty of evidence remains low due to risk of bias and imprecision.
- High-quality, independent studies are needed for future WHO recommendations.