GNPAT promotes immunosuppression in hepatocellular carcinoma by activating the plasmalogen-PPARγ pathway to drive M2 macrophage polarization - PubMed
7 hours ago
- #GNPAT
- #Immunosuppression
- #Hepatocellular carcinoma
- GNPAT promotes immunosuppression in hepatocellular carcinoma (HCC) by activating the plasmalogen-PPARγ pathway.
- GNPAT drives M2 macrophage polarization, reinforcing the immunosuppressive tumor microenvironment (TME).
- High GNPAT expression in HCC is linked to poor clinical outcomes and immunosuppressive cellular infiltration.
- GNPAT enhances HCC cell proliferation, migration, and resistance to apoptosis via plasmalogen synthesis and PPAR pathway activation.
- Targeting GNPAT inhibition could be a potential therapeutic strategy to counteract immunosuppression in HCC.