Effects of music on hepatic cytochrome P450 1A enzymes in Sprague Dawley rats - PubMed
3 hours ago
- #music effects
- #AhR signaling
- #CYP1A enzymes
- The study explored how specific music elements affect hepatic CYP1A enzymes in rats, focusing on the AhR-regulated CYP1A subfamily involved in xenobiotic metabolism.
- Exposure to fast-tempo, irregular-rhythm, and atonal-harmony (FT-IR-AH) music for 24 hours significantly increased CYP1A1 and CYP1A2 activities, Vmax, and intrinsic clearance without changing enzyme affinities.
- FT-IR-AH music induced CYP1A protein and mRNA expression in both male and female rats, with consistent results across different composers, though effects varied with gap percentages and frequency patterns.
- The induction was selective for AhR-regulated genes, not involving Nrf2-dependent antioxidant pathways, indicating a targeted activation of AhR signaling without oxidative stress.
- Findings suggest music features can modulate CYP1A expression, potentially impacting therapeutic responses, toxicity, and drug interactions.