Aptamer-Driven DNA Framework Switches for Clearing Programmed Cell Death-Ligand 1 Positive Extracellular Vesicles via Macrophage Recruitment - PubMed
4 hours ago
- #immune reprogramming
- #aptamer
- #extracellular vesicles
- Aptamer-driven DNA framework switches (MJ5C-Man6-DF) developed to clear PD-L1+ extracellular vesicles (EVs) via macrophage recruitment.
- Operates via a recognition-then-recruitment mechanism: 'off state' hides Man6, 'on state' exposes it upon PD-L1+ EV binding.
- Man6-coated EVs recruit macrophages via CD206, enhancing phagocytosis and immune clearance.
- Demonstrated exceptional stability and specificity, improving αPD-L1 therapy by 90.7% and T cell activation by 55% in vivo.
- Provides a synthetic strategy for immune reprogramming in DNA-based molecular engineering.