AcrIIA7 hijacks tracrRNA to block CRISPR-Cas system - PubMed
4 hours ago
- #RNA-binding
- #anti-CRISPR
- #CRISPR-Cas9
- AcrIIA7 inhibits the CRISPR-Cas9 system by binding to tracrRNA, preventing its association with crRNA.
- This mechanism blocks the formation of the active Cas9 ribonucleoprotein (RNP) complex.
- The study provides the first structural insight into tracrRNA-targeted anti-CRISPR activity.
- The findings highlight RNA-RNA interaction interfaces as vulnerable points in CRISPR-Cas immunity.