Comprehensive Study of Drug-Associated Severe Allergic Reactions: An Analysis of High-Risk Medications and Epidemiological Trends Based on the FAERS Database - PubMed
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- #drug-induced anaphylaxis
- #FAERS database
- #pharmacovigilance
- Study analyzed 20.7 million adverse event reports from FAERS (2004-2023) to identify drugs linked to anaphylactic shock (DIAS).
- Found 21,073 DIAS events (0.10% of all reports); median age 55 years, median weight 70 kg, higher incidence in females (56.57%).
- Top drug categories associated with DIAS: antibiotics, anesthetics, monoclonal antibodies (mAbs), and antitumor drugs.
- Specific high-risk drugs identified: amoxicillin, propofol, moxifloxacin, infliximab, omalizumab, carboplatin, paclitaxel, cefuroxime, ceftriaxone, natalizumab, rocuronium bromide.
- Disproportionality analysis (ROR > 3, PRR > 2, P < 0.001) highlighted strong signals for drugs like remifentanil, carboplatin, propofol, ceftriaxone.
- Calls for increased vigilance with β-lactam antibiotics, intravenous anesthetics, antitumor drugs, and mAbs; suggests further research on mechanisms and prevention.