An integrative multi-omics analysis leveraging Mendelian randomization and subsequent experimental validation prioritizes glutathione S-transferase mu 5 (GSTM5) as a genomic stability-related gene and

3 days ago

Integrative multi-omics analysis identifies GSTM5 as a key gene related to genomic stability in breast cancer.
GSTM5 downregulation in breast tumors is linked to promoter hypermethylation and genomic instability markers.
Low GSTM5 expression makes breast cancer cells more sensitive to PLK1 inhibition, suggesting a therapeutic vulnerability.
The study uses Mendelian randomization and experimental validation to prioritize GSTM5 from circadian rhythm-related genes.
Findings support further exploration of PLK1 inhibition as a targeted therapy for GSTM5-deficient breast cancers.

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