Circuit and molecular mechanisms underlying incubation of methamphetamine craving in the prelimbic cortex - PubMed
4 hours ago
- #prelimbic cortex
- #interneurons
- #methamphetamine craving
- The study investigates neural mechanisms behind incubation of methamphetamine craving in the prelimbic cortex.
- Somatostatin interneurons drive drug seeking during early withdrawal (day 1) via GABAergic inputs from the lateral hypothalamus.
- Parvalbumin interneurons control drug seeking after prolonged withdrawal (day 15) via glutamatergic inputs from the anteromedial thalamus.
- Single-cell RNA sequencing identified upregulated KCNC2 (Kv3.2 potassium channel) in both interneuron subtypes with specific protein modifications.
- Selective KCNC2 knockdown in SST or PV interneurons suppressed drug seeking during early or prolonged withdrawal, respectively.
- KCNC2 is highlighted as a potential phase-specific therapeutic target for methamphetamine use disorder.