Warfarin-Durian interaction: A case study bridging clinical outcomes and metabolic profiling through metabolomics - PubMed
3 hours ago
- #metabolomics
- #clinical outcomes
- #drug-food interaction
- The study examines the warfarin-durian interaction using clinical INR outcomes and metabolomics.
- Patients consuming durian showed significantly higher INR levels (3.93 ± 0.60) compared to controls (2.48 ± 0.32, p = 0.0003).
- Sulfur-containing compounds like hydrogen sulfide and trimethylsulfonium were biomarkers of durian exposure.
- Metabolomics revealed disruptions in purine metabolism (decreased adenylosuccinic acid) and the TCA cycle (increased fumaric acid).
- It is the first metabolomics-based investigation, highlighting its role in understanding drug-food interactions for patient safety.