Scap stabilizes PKM2 to promote glycolysis and enhance anti-fungal immunity in macrophages - PubMed
3 hours ago
- #PKM2
- #glycolysis
- #anti-fungal immunity
- Scap stabilizes PKM2 to enhance glycolysis and anti-fungal immunity in macrophages.
- Fungal infection reduces Scap levels, impairing cytokine production and phagocytosis in macrophages.
- Scap's role in anti-fungal immunity is independent of its canonical lipid synthesis regulation.
- Scap competitively inhibits STUB1-mediated ubiquitination and degradation of PKM2 at Lys-311.
- PKM2 agonist DASA58 boosts pro-inflammatory cytokine production and phagocytosis in macrophages.
- Myeloid-specific deletion of PKM2 mimics the effects of Scap deficiency.
- Scap is identified as a critical regulator of PKM2-mediated glycolysis in anti-fungal immunity.