Exogenous Nitric Oxide in the Treatment of Dental and Oral Diseases - PubMed
3 hours ago
- #Nitric Oxide
- #Dental Therapy
- #Oral Diseases
- Nitric oxide (NO) plays a central role in dental and oral diseases due to its signaling properties.
- Exogenous NO therapy is explored for its antibacterial, anti-inflammatory, tissue-regenerative, and antitumor effects.
- Key mechanisms include modulation of cyclic di-guanosine monophosphate, S-nitrosylation, and activation of guanylate cyclase pathways.
- NO delivery platforms like nanocarriers, hydrogels, and implant coatings are reviewed for various dental applications.
- Applications include periodontitis, dental caries, oral ulcers, orthodontic tooth movement, and oral cancer treatment.
- Most evidence comes from preclinical studies, with challenges in dosing accuracy and delivery specificity.
- Exogenous NO shows promise as an adjunctive therapy in dental medicine despite current limitations.