Brucella Omp25 activates the unfolded protein response to promote intracellular proliferation and inflammation - PubMed
3 hours ago
- #Inflammation
- #Unfolded Protein Response
- #Brucella
- Brucella Omp25 activates the unfolded protein response (UPR) to promote intracellular proliferation and inflammation.
- Omp25 binds to the ER chaperone BiP, activating UPR sensors PERK, IRE1α, and ATF6, which modulates ER homeostasis for bacterial replication.
- Omp25 enhances inflammatory cytokine expression via the BiP-IRE1α-NF-κB signaling axis.
- Omp25-deleted strains show impaired intracellular replication, reduced UPR activation, and attenuated inflammatory gene induction.
- Mice infected with an omp25 mutant strain exhibit lower bacterial burdens and milder tissue pathology compared to wild-type infection.
- Omp25 is a potential target for therapeutic interventions and next-generation attenuated vaccines.