Multitarget mechanisms and clinical integration of traditional Chinese medicine in breast cancer - PubMed
8 hours ago
- #Multitarget Therapy
- #Breast Cancer
- #Traditional Chinese Medicine
- Traditional Chinese Medicine (TCM) offers a multi-targeting approach for breast cancer, addressing challenges like drug resistance and side effects from conventional therapies.
- Bioactive TCM components, such as Wogonin and Resveratrol, inhibit tumor growth by modulating oncogenic pathways like PI3K/Akt and MAPK, and reverse multidrug resistance by targeting ABC transporters.
- Clinical integration of TCM helps mitigate toxicities from chemotherapy and radiotherapy, improving patients' quality of life and treatment tolerance, with Medicinal-Food Homology herbs supporting long-term care.
- This review synthesizes evidence from 2012-2025, highlighting TCM's role in personalized, integrated cancer therapy models to enhance immunity and reduce treatment-related morbidity.