The YY1-KIF15-PRDX1 axis promotes gastric cancer progression by inducing mitochondrial ROS imbalance - PubMed
7 hours ago
- #Mitochondrial ROS
- #Gastric Cancer
- #YY1-KIF15-PRDX1 Axis
- KIF15 is overexpressed in gastric cancer and linked to advanced stage, metastasis, and poor prognosis.
- KIF15 promotes cancer stem cell properties, proliferation, migration, invasion, and cisplatin resistance by stabilizing PRDX1 to reduce hydroperoxides and maintain mitochondrial function.
- YY1 transcriptionally activates both KIF15 and PRDX1, forming a regulatory axis that drives tumor growth, metastasis, and chemoresistance via mitochondrial ROS imbalance.