Healthy lifestyle and Alzheimer's disease in individuals with hyperlipidemia: A prospective cohort study - PubMed
3 hours ago
- #Alzheimer's disease
- #Healthy lifestyle
- #Hyperlipidemia
- The study investigates the association between healthy lifestyle behaviors and Alzheimer's disease (AD) risk in individuals with hyperlipidemia.
- A cohort of 241,642 dementia-free participants from the UK Biobank was analyzed, with a median follow-up of 14.5 years.
- A weighted lifestyle score (0-7) was used, derived from seven factors, and categorized into five tiers.
- Hyperlipidemia was defined as lipid-lowering medication use or LDL-cholesterol ≥ 4.0 mmol/L.
- Over the follow-up period, 1728 AD cases occurred, with 977 cases among 104,082 individuals with hyperlipidemia.
- Unhealthy lifestyle was associated with elevated AD risk (HR: 1.17; 95% CI: 1.02-1.35), while healthier tiers showed progressively lower risk (HR=0.85 and 0.74).
- The associations were significant among individuals with hyperlipidemia but not statistically significant among those without hyperlipidemia.
- The study concludes that healthy lifestyle patterns are associated with lower AD risk in individuals with hyperlipidemia, with greater risk reductions for healthier lifestyle tiers.