Human microphysiological systems of aging recreate the in vivo process expediting evaluation of anti-geronic strategies - PubMed
4 hours ago
- #regenerative medicine
- #aging research
- #microphysiological systems
- A human microphysiological system (MPS) using iPSC-derived cells models the white adipose tissue-liver axis to study aging and rejuvenation.
- The system incorporates heterochronic human serum and recapitulates aging-associated hallmarks, like gene expression shifts and oxidative DNA damage, within 4 days.
- It reveals unknown signaling networks, sexual polymorphisms of aging, tissue memory of age, and cross-tissue effects of aging between fat and liver.
- A custom machine learning model is developed to assess biological age, aiding in biomarker discovery and testing of anti-aging strategies.
- The approach accelerates evaluation of anti-geronic interventions and helps translate findings from rodent studies to human aging mechanisms.