FUS is an N1- and N6-methyladenosine-binding protein - PubMed
4 hours ago
- #neurodegenerative disorders
- #methyladenosine
- #FUS protein
- FUS is a protein that binds to N1- and N6-methyladenosine (m1A and m6A).
- Mutations or increased expression of FUS can lead to neurodegenerative diseases like ALS and FTLD.
- FUS interacts with methylated adenosines in CAG repeat RNA, causing its redistribution to the cytoplasm.
- Co-localization of FUS with CAG repeat RNA in the cytosol is reduced by depletion of m6A/m1A writer proteins or overexpression of eraser proteins.
- Binding to methylated CAG repeat RNA makes FUS less dynamic in cells.
- The study highlights the role of m1A and m6A in FUS-RNA interaction, affecting its subcellular distribution and mobility.
- Targeting FUS-methylated adenosine interactions could be a therapeutic strategy for FUS proteinopathy.