Kinase KEY1 controls pyrenoid condensate size throughout the cell cycle by disrupting phase separation interactions - PubMed
3 hours ago
- #biomolecular condensates
- #kinase regulation
- #cell cycle
- Kinase KEY1 regulates the size and number of pyrenoid condensates in Chlamydomonas reinhardtii throughout the cell cycle.
- KEY1 promotes the dissolution of pyrenoid condensates during cell division by disrupting interactions between Rubisco and EPYC1 via phosphorylation.
- A biophysical model was developed to explain KEY1-mediated regulation of condensate size, number, and position.
- The study provides insights into the regulation of biomolecular condensates, which are crucial for cellular organization and function.
- Funding for the research was provided by NSF, DOE, and NIH.