Mechanistic insights into aging and longevity: Implications for ovarian function and health - PubMed
4 hours ago
- #longevity-pathways
- #ovarian-aging
- #therapeutic-interventions
- Ovarian aging involves follicular reserve depletion, mitochondrial dysfunction, oxidative stress, and endocrine decline.
- Key mechanisms include telomere attrition, DNA damage, impaired autophagy, inflammation, and dysregulation of longevity pathways (PI3K/AKT/mTOR, AMPK, sirtuins).
- Therapeutic strategies include mTOR inhibitors, AMPK activators, antioxidants, mitochondrial protectants, and autophagy regulators.
- Promising compounds: rapamycin, metformin, resveratrol, and melatonin.
- Nutritional and lifestyle modifications may support pharmacological interventions.
- Research aims to delay menopause, preserve fertility, and improve women's healthspan.