Nanozyme Catalysis Restores Hair Follicle Integrity by Reversing Peroxisomal Collapse - PubMed
12 hours ago
- #nanozyme
- #alopecia
- #peroxisome
- Peroxisomal dysfunction is identified as a key factor in hair follicle aging and loss.
- Transcriptomic analysis shows downregulation of peroxisome-related pathways in alopecia patients.
- Nudt7-deficient mice exhibit hair thinning and oxidative stress, mirroring human alopecia symptoms.
- Catalytic nanozymes (HA-Hem) mimic peroxisomal catalase activity to restore metabolic balance and reduce oxidative damage.
- Nanozyme treatment enhances PPARα expression, improving peroxisomal biogenesis and lipid metabolism.
- The therapy outperforms minoxidil in regenerative responses and works in immunodeficient models.
- Spatial transcriptomics reveals activation of regenerative programs and increased expression of keratin-associated proteins.