Bilberry (Vaccinium myrtillus L.) extract alleviates gestational diabetes mellitus by coordinating TGR5/FXR signaling via a gut microbiota-bile acid axis - PubMed
3 hours ago
- #bilberry extract
- #gut microbiota
- #gestational diabetes
- Bilberry extract (VME) alleviates gestational diabetes mellitus (GDM) in rats.
- VME improves metabolic disturbances like hyperglycemia, insulin resistance, and inflammation.
- The extract remodels gut microbiota, increasing beneficial Lactobacillus.
- VME alters bile acid (BA) pool, elevating HDCA and reducing CA and CDCA.
- Changes in BA activate TGR5 and inhibit FXR, stimulating GLP-1 secretion.
- The study suggests a gut microbiota-BA-TGR5/FXR-GLP-1 pathway for VME's anti-GDM effect.