Circulating exhausted CD8+ effector memory cells differentiate immune checkpoint inhibitor-induced liver injury from other acute immune-mediated liver injuries - PubMed
7 hours ago
- #immune checkpoint inhibitor
- #CD8+ T-cells
- #liver injury
- Immune checkpoint inhibitors can cause liver injury (ChILI), a serious side effect managed with high-dose steroids.
- No specific biomarker currently exists to distinguish ChILI from other liver injuries like autoimmune hepatitis (AIH) or drug-induced liver injury (DILI).
- Study identified circulating exhausted CD8+ effector memory T-cells (expressing CD38, HLA-DR, CXCR3) as potential biomarkers for ChILI.
- These cells show increased granzyme, CD69, and exhaustion markers (CTLA-4, PDCD1, HAVCR2) compared to other CD8+ subsets.
- Liver tissue analysis found more resident CD8+ T-cells and upregulated CXCR-related genes in ChILI vs. DILI/AIH.
- Plasma cytokines sCD27 and PD-1 were elevated in ChILI patients.
- Findings suggest distinct immune pathways in ChILI, aiding differentiation from other acute immune-mediated liver injuries.