Fueling the Fire: Metabolic Dysfunction and Senescence as Drivers of Lung Aging and Disease - PubMed
5 days ago
- #Senescence
- #Lung Disease
- #Aging
- Cellular senescence is a key driver of chronic lung diseases like pulmonary fibrosis, COPD, and asthma.
- Mitochondrial dysfunction and the '4 Ms' (morphology, mitophagy, metabolism, metabolites) play a significant role in senescence pathways.
- The review discusses healthy lung aging, senescence-related pathomechanisms in chronic lung diseases, and current therapeutic targets.
- Emerging concepts and knowledge gaps are highlighted to improve therapeutic strategies and future research.