CircRNA-encoded RIPK1-98 protein drives lung adenocarcinoma progression - PubMed
3 hours ago
- #therapeutic target
- #circRNA
- #lung adenocarcinoma
- CircRNA-encoded RIPK1-98 protein is identified as a driver of lung adenocarcinoma (LUAD) progression.
- RIPK1-98, encoded by circRIPK1, is functionally distinct from its parental gene product RIPK1.
- RIPK1-98 modulates CDK2-dependent cell-cycle regulation, promoting tumor proliferation.
- The protein serves as a biomarker for cell-cycle progression in LUAD and a potential therapeutic target.
- Findings highlight RIPK1-98's role in overcoming resistance to treatments like osimertinib.