Discovery of SD-965 as a Potent, Selective, and Efficacious STAT3 PROTAC Degrader - PubMed
3 hours ago
- #STAT3
- #PROTAC
- #Cancer Therapy
- Discovery of SD-965 as a potent, selective, and efficacious STAT3 PROTAC degrader.
- STAT3 is a promising therapeutic target for human cancers and other diseases.
- SD-965 effectively induces rapid, complete, and durable depletion of STAT3 protein in mouse and human xenograft tumor tissues.
- SD-965 achieves tumor regression in human leukemia and lymphoma xenograft models with weekly administration and no toxicity.
- SD-965 is a promising candidate for further evaluation in treating human cancers and other diseases.