Preserving the UFMylation-cilium axis mitigates blue light-induced retinal degeneration - PubMed
7 hours ago
- #retinal degeneration
- #blue light damage
- #UFMylation
- Blue light damage (BLD) is linked to ocular diseases like age-related macular degeneration and dry eye diseases.
- Photoreceptor cilium disruption is identified as a key event in BLD.
- UFMylation of kinesin family member 11 (KIF11) decreases under BLD conditions.
- UFL1, the sole ligase for UFMylation, localizes to the basal body and is essential for maintaining photoreceptor cilia.
- Blue light exposure disrupts UFL1 localization at the basal body, leading to ciliary defects and photoreceptor dysfunction.
- Ufl1 knockout mice show similar ciliary defects and retinal impairments.
- Enhancing UFMylation or ciliogenesis via intravitreal injection can mitigate blue light-induced retinal damage.
- Targeting the UFMylation-cilium axis is a promising therapeutic strategy for BLD-associated retinal diseases.