Migrasome-transported PTGES amplifies the PGE2 cascade in SPP1+ macrophages to drive oral leukoplakia carcinogenesis - PubMed
19 hours ago
- #Oral Carcinogenesis
- #Migrasome
- #Macrophage Phenotype
- Migrasomes are detectable in oral leukoplakia (OLK) and oral squamous cell carcinoma (OSCC), with higher abundance in OSCC.
- Migrasomes from transformed oral carcinoma cells enhance interactions with macrophages to promote carcinogenesis.
- Uptake of PTGES-enriched migrasomes by macrophages increases PTGES expression and PGE2 secretion, inducing an SPP1+ macrophage phenotype.
- This migrasome-mediated mechanism drives macrophage migration and proliferation, contributing to OLK carcinogenesis.
- Migrasomal PTGES is proposed as a biomarker for early OSCC detection and a potential therapeutic target.