Tumor-restraining fibroblasts emerge after chemotherapy specifically in responders - PubMed
5 days ago
- #Chemotherapy
- #Fibroblasts
- #Cancer Research
- Ma et al. identified PTGER3+ cancer-associated fibroblasts (CAFs) induced by neoadjuvant chemotherapy in bladder cancer patients.
- These CAFs undergo lipid oxidation reprogramming, enhancing CD8+ T cell function.
- The study highlights the role of these CAFs in remodeling the tumor microenvironment and restraining tumor progression.
- The findings were published in Cancer Cell (DOI: 10.1016/j.ccell.2026.02.009).
- R.K. serves as an advisor and consultant for BioLamina AB, as disclosed in the conflict of interest statement.