Exposed phosphatidylserine is an inhibitory molecule in T cell exhaustion - PubMed
3 hours ago
- #phosphatidylserine
- #immunotherapy
- #T cell exhaustion
- Exposed phosphatidylserine (PS) acts as an inhibitory molecule in T cell exhaustion.
- PS is externalized on live CD8 T cells during chronic infections like LCMV.
- Chronic antigen stimulation sustains PS externalization on T cells.
- PS-targeting antibody (mch1N11) treatment expands LCMV-specific CD8 T cell responses.
- Exposed PS suppresses dendritic cell immunostimulatory phenotypes, limiting CD8 T cell responses.
- Combination of PS-targeting antibody with anti-PDL1 improves viral control.
- PD1+ CD8 T cells from human tumors also expose PS.
- PS functions as a 'non-classical' extrinsic inhibitory molecule in T cell exhaustion.