Distinct metabolic signatures of Alzheimer's and Parkinson's disease revealed through genetic overlap - PubMed
3 hours ago
- #Metabolomics
- #Genetic Architecture
- #Neurodegenerative Diseases
- AD and PD exhibit distinct metabolic-genetic profiles; AD aligns with cardiometabolic diseases like BMI and type 2 diabetes, while PD shows opposing patterns.
- Mendelian randomization suggests causal effects of lipoprotein subclasses, glutamine, and proglucagon on AD risk, with opposite or null effects in PD.
- Shared genetic loci for AD and metabolites are enriched in lipid metabolism, whereas PD loci relate to mitochondrial function and stress-response pathways.