How to train your rodent: Recommendations for the preclinical study of exercise-induced benefits in metabolic research - PubMed
6 hours ago
- #rodent models
- #metabolic research
- #exercise
- Regular physical activity is fundamental for health and longevity, with exercise benefiting metabolic parameters.
- Animal models, especially rodents, are crucial for understanding the biological responses to exercise due to challenges in human studies.
- Precise exercise designs and diverse genetic models are vital for uncovering mechanistic pathways and informing strategies against chronic diseases.
- Recommendations for designing preclinical exercise interventions and measuring key metabolic adaptations in rodents are still lacking.
- Rigorous control in exercise studies is necessary to enhance animal-to-human translation and ensure reproducibility.
- Key experimental considerations include protocol design, exercise modality, sex, age, housing temperature, and circadian rhythm.
- Standardization and translation in future preclinical exercise studies are emphasized to guide best practices.