The Effect of AZD5153 on Radiosensitivity in Pancreatic Cancer Cells Through ATM-chk1 Pathway - PubMed
4 hours ago
- #radiosensitivity
- #pancreatic cancer
- #ATM-chk1 pathway
- AZD5153, a BRD4 inhibitor, enhances radiosensitivity in pancreatic cancer cells.
- The study shows AZD5153's anti-proliferative effects on Capan2 and PANC1 cells.
- Combination of AZD5153 and radiotherapy improves anti-tumor efficacy in vivo.
- AZD5153 causes G2/M phase cell cycle arrest and increases DNA damage markers.
- Inhibition of the ATM-chk1 pathway by AZD5153 impairs DNA damage repair.
- Targeting the ATM-chk1 pathway may help overcome radioresistance in pancreatic cancer.