DSCAML1+ extracellular vesicles revealed by single-vesicle proteomics as a novel biomarker and therapeutic target in myocardial infarction - PubMed
3 hours ago
- #Biomarker
- #Myocardial Infarction
- #Extracellular Vesicles
- DSCAML1+ extracellular vesicles identified as a novel biomarker and therapeutic target for myocardial infarction (MI).
- Single-vesicle proteomics revealed 21 differentially expressed proteins (DEPs) in MI patients, with 11 unique to MI.
- DSCAML1, CR1, ACE2, FN1, CDH15, and C5b‑9 were elevated in MI patients' extracellular vesicles (EVs).
- EVs were categorized into 17 subpopulations, with clusters 1 (DSCAML1), 8 (ALCAM), and 9 (CR1) most enriched in MI.
- DSCAML1-enriched EVs (DSCAML1-EVs) promote cardiomyocyte proliferation and endothelial cell activity, enhancing myocardial repair and angiogenesis via the EREG/ERK pathway.
- Study suggests DSCAML1-positive EVs have dual potential as a diagnostic biomarker and therapeutic target for MI.