Myelin sheaths persist for weeks following axon degeneration - PubMed
4 hours ago
- #axon-degeneration
- #myelin
- #neuroscience
- Myelin sheaths can persist for weeks after axon degeneration.
- Following axon injury, myelin sheaths lose compaction and slowly shrink.
- Oligodendrocyte homeostasis is largely maintained after injury, with only brief changes in myelin sheath plasticity.
- Clearance of axon debris is delayed if the axon is myelinated.
- Microglia rarely engage with injured axons or de-axoned myelin sheaths.
- The study highlights the stability of myelinating oligodendrocytes post-injury.