CBP phosphorylation maintains intestinal homeostasis by supporting the stem cell niche through versican - PubMed
8 hours ago
- #CBP phosphorylation
- #intestinal stem cell niche
- #versican
- CBP phosphorylation is crucial for maintaining intestinal homeostasis by supporting the stem cell niche through versican.
- Impaired CBP phosphorylation leads to increased CBP-p53 binding, reduced versican expression, and impaired intestinal epithelial cell proliferation.
- Deletion of p53 in CBPAA mice restores versican expression and reverses colonic abnormalities.
- Versican replenishment and phosphomimetic CBP mutants rescue versican expression and stemness in organoids.
- Colonic tissues from ulcerative colitis patients show impaired CBP phosphorylation and decreased versican, highlighting clinical relevance.
- Versican is identified as a potential therapeutic target for inflammatory bowel disease.