LENG8 mediates RNA nuclear retention and degradation in eukaryotes - PubMed
3 hours ago
- #RNA export
- #RNA nuclear retention
- #RNA degradation
- LENG8 is identified as a conserved RNA nuclear retention and degradation factor in eukaryotes.
- LENG8 forms the REX complex with PCID2 and SEM1, acting as a dominant-negative factor for the TREX-2 mRNA export factor.
- Loss of LENG8 leads to cytoplasmic leakage of misprocessed mRNAs and noncoding RNAs.
- LENG8 promotes nuclear RNA degradation via interactions with the RNA exosome adaptor PAXT.
- The study reveals a conserved RNA quality-control mechanism ensuring only correctly processed RNAs are exported.