UBC9-mediated SUMOylation of CORO1C drives lung adenocarcinoma progression via Arp2/3-dependent cytoskeletal remodeling - PubMed
8 hours ago
- #UBC9
- #CORO1C
- #SUMOylation
- UBC9, the sole SUMO E2-conjugating enzyme, is upregulated in lung adenocarcinoma (LUAD) and high expression correlates with poor outcomes.
- UBC9 ablation suppresses LUAD cell proliferation, migration, invasion, and tumorigenesis both in vitro and in vivo.
- Coronin-1C (CORO1C) is identified as a key substrate of UBC9-mediated SUMOylation via immunoprecipitation-mass spectrometry.
- SUMOylation of CORO1C at lysines K19, K311, and K440 enhances its binding to the Arp2 complex.
- This enhanced binding promotes actin-based cytoskeletal remodeling, driving malignant behaviors in LUAD cells.
- The study reveals a novel regulatory axis where UBC9-dependent SUMOylation of CORO1C orchestrates Arp2/3-mediated cytoskeletal dynamics to advance LUAD progression.
- Findings highlight CORO1C as a new SUMOylation target in LUAD and suggest a potential therapeutic avenue for advanced disease.