Tau phosphorylation homeostasis: Mechanisms, targets, and therapeutic implications in Alzheimer's disease - PubMed
4 hours ago
- #Alzheimer's disease
- #Tau phosphorylation
- #Therapeutic targets
- Neurofibrillary tangles, composed of hyperphosphorylated tau, are a key feature of Alzheimer's disease (AD).
- Therapeutic strategies targeting neurofibrillary tangles directly have shown limited success, shifting focus to tau phosphorylation dysregulation.
- Tau phosphorylation is essential for microtubule stability and neuronal function, but hyperphosphorylation leads to neurodegeneration.
- Restoring tau phosphorylation homeostasis is emerging as a promising therapeutic approach for AD.
- The review discusses physiological and pathological roles of tau phosphorylation, its role in AD, and recent drug development targeting kinases and phosphatases.
- Tau phosphorylation biomarkers have diagnostic value and potential applications in precision treatment strategies for AD.