Maternal smoking based on pre-birth health examination and risk of neurodevelopmental disorders in offspring: insights from a Korean mother-child cohort - PubMed
a day ago
- #Neurodevelopmental Disorders
- #Cohort Study
- #Maternal Smoking
- Maternal smoking is associated with increased risks of neurodevelopmental disorders in offspring, including intellectual disability, autism spectrum disorder (ASD), and attention-deficit/hyperactivity disorder (ADHD).
- The study analyzed data from a nationwide Korean mother-child cohort, including 861,876 offspring born between 2009 and 2018, with maternal smoking status categorized as never, former, or current smokers.
- Offspring of mothers with any history of smoking had a higher cumulative incidence of neurodevelopmental disorders compared to those of never smokers (all log-rank P < 0.001).
- After adjustment, offspring of former smokers had hazard ratios (HRs) of 1.21 for intellectual disability, 1.29 for ASD, and 1.18 for ADHD compared to never smokers.
- Offspring of current smokers had even higher risks, with HRs of 1.44 for intellectual disability, 1.52 for ASD, and 1.35 for ADHD.
- The study supports public health efforts to reduce smoking in women of reproductive age to mitigate risks of neurodevelopmental disorders in offspring.