Zinc finger proteins (ZFPs) in health and disease - PubMed
4 hours ago
- #Gene regulation
- #Therapeutic targets
- #Zinc finger proteins
- Zinc finger proteins (ZFPs) are a superfamily of DNA and RNA-binding proteins that regulate gene expression and cellular homeostasis.
- ZFPs play critical roles in various human diseases, including cancer, neurological disorders, and autoimmune diseases.
- Dysregulated ZFP activity contributes to disease pathogenesis, with ischemic stroke as a key example.
- ZFPs influence stroke risk factors like hypertension, hyperglycemia, and atherosclerosis, and post-ischemic injury cascades such as neuroinflammation and blood-brain barrier disruption.
- Therapeutic strategies targeting ZFPs include small-molecule modulators, PROTACs, ZFN-based gene editing, and nanocarrier delivery systems.
- High-throughput computational screening is being used to develop precision therapies targeting ZFPs.
- The review provides a framework for future research on ZFPs as therapeutic targets in ischemic stroke and other diseases.