The Benefits and Risks of Glucagon-Like Peptide-1 Receptor Agonists on Ocular Diseases: A Narrative Review - PubMed
7 hours ago
- #GLP-1 receptor agonists
- #ocular diseases
- #diabetes management
- GLP-1 receptor agonists (GLP-1RAs) are used for managing type 2 diabetes and obesity by mimicking the GLP-1 hormone, enhancing insulin secretion, and promoting weight loss.
- Emerging concerns link GLP-1RAs to ocular pathologies like retinal vascular occlusion, vitreous hemorrhage, diabetic retinopathy, and more.
- Potential benefits of GLP-1RAs include positive effects on glaucoma and idiopathic intracranial hypertension.
- The review highlights harmful mechanisms such as retinal microvascular dysregulation, inflammation, oxidative stress, and metabolic shifts.
- A literature search was conducted using multiple databases to analyze the ocular effects of GLP-1RAs from 2014 to 2025.
- Understanding the risks and benefits of GLP-1RAs is crucial for clinicians to manage ocular conditions safely in patients using these drugs.