Maltol induces diabetic fragility fractures by disrupting the balance of bone remodeling - PubMed
3 hours ago
- #Diabetes
- #Food Additive
- #Bone Fragility
- Maltol, a common food additive, is identified as a new risk factor for bone fragility in type 2 diabetes, linked to increased fracture risk.
- Mechanistically, maltol disrupts bone remodeling by inhibiting osteoblast differentiation via Wnt/β-catenin and promoting osteoclast maturation through NF-κB signaling.
- The effects of maltol on bone are worsened under hyperglycemic conditions but mitigated by insulin, highlighting the role of metabolic context.
- Findings suggest the need to reevaluate food additive safety with disease-specific dietary guidelines to reduce fracture risk in diabetic individuals.