Astrocytes in neuroinflammation and brain cancer - PubMed
8 hours ago
- #neuroinflammation
- #astrocytes
- #glioblastoma
- Astrocytes are active regulators in glioma progression and undergo state transitions due to tumor cues, inflammation, and therapy stress.
- Major astrocyte programs are identified across perivascular, invasive-margin, and hypoxic niches using advanced technologies like single-cell transcriptomics.
- Key signaling pathways (IL-6/STAT3, NF-κB, interferon, TGF-β) drive metabolic and chromatin changes that stabilize pro-tumor astrocyte phenotypes.
- A 4D spatiotemporal mapping framework is proposed to track astrocyte trajectories and predict therapy-induced state shifts.
- A glial liquid biopsy concept focuses on separating tumor-derived and astrocyte-derived analytes for diagnostics.
- State-aware interventions include pharmacologic modulation and RNA therapeutics, aiming to restore protective functions while enhancing therapies like immunotherapy.
- Clinical translation priorities involve longitudinal sampling, spatial atlases, and combining astrocyte normalization with existing treatments.