Immune profiling links autoimmune hepatitis to human herpesvirus 6 and relaxin receptor antigens - PubMed
8 hours ago
- #Human herpesvirus 6
- #Autoimmune hepatitis
- #Relaxin receptor
- Autoimmune hepatitis (AIH) is a chronic disease characterized by IgG elevation and specific autoantibodies.
- A novel humoral signature in AIH includes antibodies against SLA/LP, DIP2A, and RXFP1.
- DIP2A antibodies cross-react with a 9-amino acid sequence from human herpesvirus 6 (HHV6) U27 protein.
- AIH patients with anti-DIP2A antibodies show higher HHV6 IgG titers, suggesting viral reactivation.
- Anti-RXFP1 antibodies in AIH inhibit relaxin-2 signaling, potentially contributing to disease pathogenesis.
- The study links HHV6 reactivation and anti-RXFP1 antibodies to AIH disease mechanisms.