ZEB1 integrates stemness, differentiation blockade and immune suppression to orchestrate osteosarcoma aggressiveness - PubMed
3 hours ago
- #stemness
- #osteosarcoma
- #ZEB1
- ZEB1 plays a crucial role in osteosarcoma aggressiveness by integrating stemness, differentiation blockade, and immune suppression.
- In OS models, ZEB1 loss reduces stemness, impairs growth, increases chemotherapy sensitivity, and restores osteoblastic differentiation.
- ZEB1 deletion in vivo hinders tumor growth and metastasis while decreasing pro-tumoral macrophage infiltration.
- Gene expression profiling shows ZEB1 suppresses oncogenic pathways and inflammatory mediators; its restoration rescues the aggressive phenotype.
- Targeting ZEB1 and differentiation-based strategies may offer promising therapeutic avenues for osteosarcoma treatment.