Celastrol triggers CAV-1-mediated mitochondrion cholesterol metabolism and mitophagy to suppress liver cancer - PubMed
4 hours ago
- #Liver Cancer
- #Mitophagy
- #Celastrol
- Celastrol (CeT), derived from Tripterygium wilfordii Hook. f., shows anti-cancer properties by modulating lipid metabolism.
- CeT induces mitophagy in liver cancer by disrupting the CAV-1/SCP2 axis, leading to mitochondrial cholesterol accumulation.
- Mitochondrial cholesterol overload increases ROS levels, dissipates membrane potential, and triggers mitophagy, inhibiting cancer growth.
- In vivo studies in xenograft models confirm CeT's tumor-suppressing effects via CAV-1 inhibition and mitophagy activation.
- Targeting organelle-specific cholesterol metabolism presents a novel therapeutic strategy in oncology.